The frescos in the Peribleptos Church, dating between 1348 & 1380, are a very rare surviving late Byzantine cycle, crucial for the understanding of Byzantine art.
Mystras was also the last centre of Byzantine scholarship; the Neoplatonist philosopher George Gemistos Plethon lived there until his death in 1452. He & other scholars based in Mystras influenced the Italian Renaissance, especially after he accompanied the emperor John VIII Palaeologus to Florence in 1439.
The last Byzantine emperor, Constantine XI, was despot at Mystras before he came to the throne. Demetrius Palaeologus the last despot of Morea, surrendered the city to the Ottoman emperor Mehmed II in 1460. The Venetians occupied it from 1687 to 1715, but otherwise the Ottomans held it until 1821 & the beginning of the Greek War of Independence. It was abandoned by King Otto for the newly rebuilt Sparta.
In 1989 the ruins, including the fortress, palace, churches & monasteries, were announced UNESCO World Heritage Site.